Research

Research interestsserotonin

     The overall goal of our research is to promote functional recovery following spinal cord injury.

     Functional recovery following injuries of the central nervous system (CNS) is limited because severed axons are unable to regrow. This inability to regenerate is caused by various factors including growth inhibitory factors in the central nervous system and intracellular properties of injured neurons. Nevertheless, moderate recovery following brain or spinal cord injuries occurs. The underlying mechanisms for this recovery lies in the ability of spared and injured CNS circuitries to rearrange, generally termed as plasticity. To promote functional recovery following spinal cord injury we are currently focusing on the following strategies:
a) trying to understand injury induced plasticity and attempting to enhance this naturally occurring repair mechanism, b) unravel how rehabilitative training promotes plasticity, and what limits training effciay in the chronic setting, c) Promoting regeneration of lesioned axons by addressing various regeneration restricting factors in combined treatments.

Methodology

     The methods used in our laboratory range from various experimental approaches to promote plasticity and regeneration (including rehabilitative training), to histological examinations, behavioral tests (sensory and motor), high speed kinematic and in vivo electrophysiological assessments.

Facilities

     Our facilities include a tissue culture area, a histology lab, a darkroom for confocal microscopy and a laboratory fully equipped for surgeries and physiological experiments.

Funding

We would like to aknowledge generous funding support over the last years from the